Why so much AKI lately?

Regular readers of our, and other, journals have probably noted an increasing number papers on acute kidney injury (AKI) in hospitalized children. Why is this? Independent any actual change incidence, a major contributor to such studies has been better definitions pediatric AKI. Older may relied derived adults, which because reliance serum creatinine underestimate small children especially newborns. In the past decade, general consensus developed AKI definition, referred as Kidney Disease Improving Global Outcomes (KDIGO) guidelines. Specific neonatal (nKDIGO) also developed. With these tools hand, clinical investigators begun reassess risk host settings. A nice example this type study reported current volume The Journal by Coggins et al. These examined neonates with sepsis, comparing group proven sepsis matched who had negative investigations. findings are sobering. Twenty percent met nKDIGO criteria for Although not-insignificant controls (8%) AKI, severity was greater infected babies. presence independently associated mortality. It should be that most babies rather mild involvement, few required renal replacement therapy. Indeed, earlier era, would not diagnosed As authors note, we really do understand long-term consequences Data adults point increased chronic disease hypertension, but data lacking. Papers need careful follow up function blood pressure children, well attention potentially modifiable factors contribute increasingly recognized phenomenon. Article page 185 ▸ Acute Injury Associated Late-Onset Neonatal Sepsis: Matched Cohort StudyThe PediatricsVol. 231PreviewTo determine incidence within 7 days evaluation assess duration association between 30-day Full-Text PDF